A variety of physical and chemical approaches to reduce mycotoxin contamination have been utilized, but large-scale, practical, cost-effective, non-toxic methods for complete detoxification of all mycotoxin-containing feedstuffs are not available. Generally, strategies have encompassed adsorption (i.e. binders), biological detoxifiers (e.g. enzymes), or physiological modifiers aiding the animal in detoxifying and/or recovery from exposure. Due to differences in chemical characteristics of each mycotoxin (polarity, solubility, size, shape), one strategy may work well for a particular mycotoxin, but cannot be universally applied across all mycotoxin. Additionally, differences in animal age, GIT anatomy, GIT passage rate, and activation/detoxifying differences between animals will need to be considered for future innovations in the mycotoxin space.